Investigating T cell populations for immune cell exhaustion in myalgic encephalomyelitis/chronic fatigue syndrome
نویسندگان
چکیده
Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a devastating disease that confines ~65 million people worldwide to life of pain, severe exhaustion, cognitive deficits, flu-like symptoms, and postexertional malaise. We previously discovered decreased glycolysis, mitochondrial membrane potential, increased fatty acid oxidation in ME/CFS T cells. These features are commonly found exhausted cells, reversible state seen chronic viral infections decreases cell proliferation, survival, cytotoxicity. Our study evaluated whether subsets circulate with by analyzing CD4+ CD8+ cells for associated inhibitory receptors transcription factors. were isolated from 20 patients sedentary control blood samples measured ~15–17 markers at rest after stimulation using FACSymphony analyzer. Markers included population identifiers naïve, effector, memory, regulatory, helper significantly higher abundances frequencies factors related exhaustion general within PD-1+ samples. Half the cohort showed PD-1 memory than group. Moreover, exhibited levels Lag3, CTLA4, T-bet various subsets. This research detects novel immune dysfunction may suggest new treatment options. Supported Alfred P. Sloan Foundation National Institute Neurological Disorders Stroke (NINDS), NIH (U54NS105541).
منابع مشابه
Chronic fatigue syndrome/myalgic encephalitis.
All letters are subject to editing and may be shortened. Letters should be sent to the BJGP office by e-mail in the first instance, addressed to [email protected] (please include your postal address). Alternatively, they may be sent by post (please use double spacing and, if possible, include a MS Word or plain text version on an IBM PC-formatted disk). We regret that we cannot notify authors...
متن کاملCharacterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
Objective: Natural Killer (NK) cells are classified into different phenotypes according to the expression of the surface markers CD56 and CD16. Each NK cell phenotype has a role in the immune response through cytotoxic activity or cytokine production. Reduced NK cell cytotoxic activity is a consistent finding in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and inves...
متن کاملt cell immune responses in psoriasis.
a central role for t cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. the goal of this study is to summarise currently available data on the importance of t cells in psoriasis pathogenesis. a systematic review of the english medical literature was conducted by searching pubmed, embase, isi w...
متن کاملChronic fatigue syndrome or myalgic encephalomyelitis.
Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a debilitating illness that affects many systems of the body, particularly the nervous and immune systems. The condition affects all age, racial, ethnic and socioeconomic groups. This article focuses on the knowledge, understanding and skills necessary to recognise, assess, manage and support patients with CFS/ME. The principles ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.229.01